PENGARUH PEMBERIAN CUKA APEL (Malus sylvestris Mill) VARIETAS MANALAGI TERHADAP KADAR TRIGLISERIDA DARAH TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIBERI DIET TINGGI LEMAK DAN DIINDUKSI ALOKSAN

Keywords:

Yuliyanti Yuliyanti

Universitas Hang Tuah Surabaya

A. Sareh Arjono Tjandra

Universitas Hang Tuah Surabaya

Herin Setianingsih

Universitas Hang Tuah Surabaya

Abstract

Hypertriglyceridemia is one of the risk factors for cardiovascular disease and acute pancreatitis (Pejic and Lee, 2006; Brahm and Hegele, 2013; Afari et al., 2015). One way to treat it by using the apple vinegar (Malus sylvestris Mill) of manalagi varieties which contained high antioxidants and acetic acid as well as more durable than the fresh fruit. The study aimed to know the effect of the Apple vinegar of manalagi varieties (Malus sylvestris Mill) to blood triglyceride levels of white male rats (Rattus norvegicus) wistar strain with high-fat diet and induced by alloxan. The study used the post test only control group design, with 24 rats samples which were divided into three groups. The negative control group (K0) only received standard diet for 24 days, the positive control group (K1) received a high-fat diet for 7 days and induced by alloxan with doses of 90 mg/kgBW of rats, and treatment group (K2) was given a high-fat diet for 7 days, induced by alloxan and received the apple vinegar (Malus sylvestris Mill) of manalagi varieties with a dose of 0,27 ml/100 g BW of rats for 14 days. The results by using one way ANOVA showed the significance value of the data p = 0,974 (p>0,05) so that there is no significant difference of the mean of blood triglycerides levels between K0, K1 and K2. This study concluded that apple vinegar (Malus sylvestris Mill) of manalagi varieties can not significantly lower the blood triglyceride levels of white male rats (Rattus norvegicus) wistar strain with high-fat diet and induced by alloxan. Further study about apple vinegar of manalagi varieties is required to define its effects.  Keywords—: High-Fat Diet, Alloxan, Triglyceride, Apple Vinegar (Malus sylvestris Mill) of Manalagi Varieties

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Afari, M. E. et al. (2015) ‘Hypertriglyceridemia-Induced Pancreatitis: A Decade of Experience in a Community-Based Teaching Hospital’, Rhode Island medical journal (2013), 98(12), pp. 40–43. Available at: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017062499&partnerID=40&md5=b7c0a6d0888ccf0a2bf0dae46106be76.

Aguilar, M. et al. (2015) ‘Prevalence of the Metabolic Syndrome in the United States, 2003-2012’, JAMA, 313(19), pp. 2011–2012.

Aprillia, D. and Susanto, W. H. (2014) ‘Pembuatan Sari Apel (Malus sylvestris Mill) dengan Ekstraksi Metode Osmosis (Kajian Varietas Apel dan Lama Osmosis)’, Jurnal Pangan dan Agroindustri, Vol.2(No.1), p. p.86-96.

Ayoub, N. et al. (2016) ‘Hepatoprotective and antidiabetic effects of apple cider vinegar ( A Prophetic Medicine Remedy ) on the liver of male rats’, 62, pp. 95–104.

Bárdos, L. and Bender, B. (2012) ‘Effect of Apple Cider Vinegar on Plasma Lipids (Model Experiment in Mice)’, Potravinarstvo, 6(1). doi: 10.5219/156.

Beheshti, Z. et al. (2012) ‘Influence of apple cider vinegar on blood lipids’, Life Science Journal, pp. 2431–2440.

Botham, K. M. and Mayes, P. . (2009) Harper Illustrated Biochemistry. 28th edn. New York: Mc Graw Hill Companies Inc.

Brahm, A. and Hegele, R. A. (2013) ‘Hypertriglyceridemia’, Nutrients, 5(3), pp. 981–1001. doi: 10.3390/nu5030981.

Brunton, L., Chabner, B. and Knollman, B. (2013) Goodman & Gilman’s The Pharmacological Basis of Therapeutics, Journal of Chemical Information and Modeling. doi: 10.1017/CBO9781107415324.004.

Ferretti, G., Turco, I. and Bacchetti, T. (2014) ‘Apple as a Source of Dietary Phytonutrients : Bioavailability and Evidence of Protective Effects against Human Cardiovascular Disease’, Food and Nutrition Sciences, 5(July), pp. 1234–1246. doi: 10.4236/fns.2014.513134.

Francini, A. and Sebastiani, L. (2013) ‘Phenolic Compounds in Apple (Malus x domestica Borkh.): Compounds Characterization and Stability during Postharvest and after Processing’, Antioxidants, pp. 181–193. doi: 10.3390/antiox2030181.

Gill, R. M. et al. (2017) ‘Prevalence of the Metabolic Syndrome in Central and South American Immigrant Residents of the Washington, DC, Area’, Journal of Nutrition and Metabolism. Hindawi, 2017(2005). doi: 10.1155/2017/9531964.

Hardisari, R. and Koiriyah, B. (2016) ‘Gambaran Kadar Trigliserida ( Metode Gpo-Pap) Pada Sampel Serum dan Plasma EDTA’, Jurnal Teknologi Laboratorium, 5.

IDF (2006) ‘Metabolic Syndrome’, in The IDF Consensus Worldwide Definition of The Metabolic Syndrome. Brussels.

Khurniyati, M. I. et al. (2015) ‘Pengaruh Konsentrasi Natrium Benzoat dan Kondisi Pasteurisasi (Suhu dan Waktu) terhadap Karakteristik Minuman Sari Apel Berbagai Varietas’, Jurnal Pangan dan Agroindustri, 3(2), pp. 523–529.

Leaf, D. A. (2008) ‘Hypertriglyceridemia: A Guide to Assessment and Treatment’, Hospital Physician, (September), pp. 17–24.

Lenzen (2007) ‘The mechanism of alloxan and streptozocin-induced diabetes’, Diabetologia, pp. 216–223.

Nestel, P. et al. (2007) ‘Metabolic syndrome: recent prevalence in East and Southeast Asian populations.’, Asia Pacific Journal of Clinical Nutrition, 16(2), pp. 362–367.

Panetta, C. J., Jonk, Y. C. and Shapiro, A. C. (2013) ‘Prospective randomized clinical trial evaluating the impact of vinegar on lipids in non-diabetics’, World of Journal of Cardiovascular Diseases, 3(April), pp. 191–196. doi: 10.4236/WJCD.2013.32027.

Pejic, R. N. and Lee, D. T. (2006) ‘Hypertriglyceridemia’, 19(3), pp. 310–316.

Rahmawati, N. (2015) Pengaruh Pemberian Cuka Apel Anna Terhadap Kadar MDA Tikus Jantan Galur Wistar (Rattus norvegicus) yang Diinduksi Parasetamol Dosis Toksik. Universitas Jember. Available at: http://repository.unej.ac.id/bitstream/handle/123456789/78679/Niki Rahmawati - 122010101048 %23.pdf?sequence=1.

Ranasinghe, P. et al. (2017) ‘Prevalence and trends of metabolic syndrome among adults in the Asia-pacific region: A systematic review’, BMC Public Health. BMC Public Health, 17(1), pp. 1–9. doi: 10.1186/s12889-017-4041-1.

Shishehbor, F. et al. (2008) ‘Apple cider vinegar attenuates lipid profile in normal and diabetic rats’, Pakistan Journal of Biological Sciences, 11(23), pp. 2634–2638. doi: 10.3923/pjbs.2008.2634.2638.

Soewondo, P. et al. (2010) ‘Prevalence of metabolic syndrome using NCEP/ATP III criteria in Jakarta, Indonesia: the Jakarta primary non-communicable disease risk factors surveillance 2006.’, Acta medica Indonesiana, 42(4), pp. 199–203.

Steel, R.G.D. and Torrie, J.H. (1991) 'Prinsip dan Prosedur Statistika Suatu Pendekatan Biometrik (Terjemahan: Bambang Sumantri)'. Jakarta: PT. Gramedia.

Suhaema and Masthalina, H. (2015) ‘Pola Konsumsi Dengan Terjadinya Sindrom Metabolik di Indonesia’, Jurnal Kesehatan Masyarakat Nasional, 9(4), pp. 340–347.

Tortora, G. J. and Derrickson, B. (2006) Principles of Anatomy and. Physiology:11th Edition. New York: Wiley.

Yulianti, S. et al. (2007) Khasiat dan Manfaat Apel. Edited by P. R. Jakarta: PT. AgroMedia Pustaka.

Yuliyanti Yuliyanti, Universitas Hang Tuah Surabaya

Mahasiswa Fakultas Kedokteran

A. Sareh Arjono Tjandra, Universitas Hang Tuah Surabaya

Dosen Fakultas Kedokteran

Herin Setianingsih, Universitas Hang Tuah Surabaya

Dosen Fakultas Kedokteran
Title PENGARUH PEMBERIAN CUKA APEL (Malus sylvestris Mill) VARIETAS MANALAGI TERHADAP KADAR TRIGLISERIDA DARAH TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIBERI DIET TINGGI LEMAK DAN DIINDUKSI ALOKSAN
Issue: Vol. 20 No. 2 (2019): JURNAL AGRITEK
Section Articles
Published: Nov 6, 2019
DOI: https://doi.org/10.33319/agtek.v20i2.28
Author
  • Yuliyanti Yuliyanti
    Universitas Hang Tuah Surabaya
    Mahasiswa Fakultas Kedokteran
  • A. Sareh Arjono Tjandra
    Universitas Hang Tuah Surabaya
    Dosen Fakultas Kedokteran
  • Herin Setianingsih
    Universitas Hang Tuah Surabaya
    Dosen Fakultas Kedokteran
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How to Cite
Yuliyanti, Y., Tjandra, A. S. A., & Setianingsih, H. (2019). PENGARUH PEMBERIAN CUKA APEL (Malus sylvestris Mill) VARIETAS MANALAGI TERHADAP KADAR TRIGLISERIDA DARAH TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIBERI DIET TINGGI LEMAK DAN DIINDUKSI ALOKSAN. JURNAL AGRI-TEK : Jurnal Penelitian Ilmu-Ilmu Eksakta, 20(2), 70–75. https://doi.org/10.33319/agtek.v20i2.28
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